科学研究实验教学平台主任

文章作者:  发布时间:2016-02-01

 

姓名: 陆军

 出生年月: 1975年1月3

 学位学历: 博士

 职称: 校聘教授

 学科专业: 生物化学与分子生物学

 联系方式: 0516-83500348

E-maillu-jun75@163.com

【个人简历】

 1.教育背景和工作简历

 1994年9月–1998年6月,江苏师范大学,生命科学学院,学士

 1999年9月–2002年6月,江苏师范大学,生命科学学院,硕士

 2003年3月–2008年6月,东南大学,基础医学院,博士

 2008年9月–2010年12月,江苏师范大学,生命科学学院,讲师

 2011年9月–2012年12月,江苏师范大学,生命科学学院,副教授

 2013年1月–至今,江苏师范大学,生命科学学院,校聘教授

 2.工作成绩及学术成果

  主要从事神经退行性疾病的信号转导与治疗研究,在该研究领域已经逐渐形成了较为明显的学科特色。相关研究在Brain(IF=9.457),The Journal of Pathology(IF=7.274),Cerebral Cortex(IF=6.844),Brain, Behavior, and Immunity(IF=5.061)等国际重要期刊发表论文27篇。论文总影响因子为107,被引用574次(其中SCI他引247次)。主要发现和结论被国内外同行在Molecular Aspects of Medicine、Neuroscience and Biobehavioral Reviews、The Journal of Pathology、Critical Care Medicine、Journal of Clinical Endocrinology & Metabolism、Free Radical Biology and Medicine等顶级和重要SCI期刊广泛引证和评述。并且,2009年发表在Neurobiology of Learning and Memory论文被该刊物评为2009年10-12月份25篇热点论文之一;2010年发表在The Journal of Pathology上的论文被该杂志主编特邀国际上该研究领域的顶尖科学家Miguel L´opez教授作了专题评论;2011年发表在Brain的成果被临床神经科学著名刊物《Neurosurgery》的主编特邀本领域著名专家对该论文作专题评论;2011年发表在Brain, Behavior, and Immunity论文被该刊物评为2011年7-9月份25篇热点论文之一。此外,发表在Brain、The Journal of Pathology和Cerebral Cortex上的这三篇论文分别在2010年和2011年被爱唯医学网(ElsevierMed.cn)列为中国作者重要发表论文。多次被国际著名刊物Cerebral Cortex、Neurobiology of Learning and Memory、Hippocampus、Brain, Behavior, and Immunity、Neurobiology of Aging、Experimental Neurology、Journal of Agricultural and Food Chemistry、The Journal of Nutrition、Molecular Nutrition and Food Research等邀请为审稿人。

 【研究领域和兴趣】

 1.型糖尿病小鼠认知缺陷的分子调控网络研究

 2.细菌脂多糖(LPS) 介导神经炎症网络的信号转导研究

 3.帕金森综合症分子机理研究

 4. 阿尔茨海默病患者(AD)分子病理学机制研究

 【承担的主要科研项目】

序号

项目名称

项目级别

项目来源

项目号

经费

(万元)

项目排序

起止日期

1

毛蕊异黄酮改善高胆固醇饲喂致小鼠神经记忆损伤的机制

国家级

国家自然科学基金委

81271225

70

1

2013.01-2016.12

2

槲皮素对老年痴呆模型小鼠的神经保护作用分子机理研究

厅局级

江苏省教育厅

09KJB180009

5

1

2009.09-2011.12

3

内质网应激介导的代谢综合症致脑损伤的分子机制及花青素干预的研究

 

国家级

国家自然科学基金委

81171012

60

2

2012.01-2015.12

4

甘薯花青素对衰老脑组织炎症损伤干预的分子机制研究

国家级

国家自然科学基金委

30950031

10

2

2010.01-2010.12

5

神经元存活信号通路介导甘薯花青素神经保护作用的机制

厅局级

江苏省教育厅

07KJA36029

15

3

2007.01-2010.12

6

紫甘薯花青素保护D-Galactosamine

/Lipopolysaccharide诱导小鼠凋亡性肝损伤的分子机制

厅局级

江苏省教育厅

09KJB180003

2

4

2009.09-2010.12


【代表性论文】

1. Dong-mei Wu, Jun Lu, Yan-qiu Zhang, Yuan-lin Zheng, Bin Hu, Wei Cheng, Zi-feng Zhang, Meng-qiu Li. Ursolic acid improves domoic acid-induced cognitive deficits in mice. Toxicology and Applied Pharmacology. 2013, In Press. (2011 IF=4.447)

2. Jun Lu, Dong-Mei Wu, Yuan-lin Zheng, Bin Hu, Wei Cheng, Zi-feng Zhang, Meng-qiu Li. Troxerutin Counteracts Domoic Acid-Induced Memory Deficits in Mice by Inhibiting CCAAT/Enhancer Binding Protein β-Mediated Inflammatory Response and Oxidative Stress. The Journal of Immunology. 2013, 190: 3466-3479. (2011 IF=5.788)

3. Zi-feng Zhang, Jun Lu, Yuan-lin Zheng, Dong-Mei Wu, Bin Hu, Qun Shan, Wei Cheng, Meng-qiu Li, Yuan-yuan Sun. Purple sweet potato color attenuates hepatic insulin resistance via blocking oxidative stress and endoplasmic reticulum stress in high-fat-diet-treated mice. The Journal of Nutritional Biochemistry. 2012, 24: 1008-1018. (2012 IF=4.552)

4. Dong-mei Wu, Jun Lu, Yuan-lin Zheng, Yan-qiu Zhang, Bin Hu, Wei Cheng, Zi-feng Zhang, Meng-qiu Li. Small interfering RNA-mediated knockdown of protein kinase C zeta attenuates domoic acid-induced cognitive deficits in mice. Toxicological Sciences, 2012, 128: 209-222. (2011 IF=4.652)

5. Jun Lu, Dong-mei Wu, Yuan-lin Zheng, Bin Hu, Wei Cheng, Zi-feng Zhang. Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice. Free Radical Biology and Medicine, 2012, 52: 646-659 (2011 IF=5.423)

6. Jun Lu, Dong-mei Wu, Yuan-lin Zheng, Bin Hu, Wei Cheng, Zi-feng Zhang, Qun Shan. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. Brain, Behavior, and Immunity, 2011, 25: 1658-1667 (2011 IF=4.72)

7. Yong-Jian Wang, Jun Lu, Zi-hui Zheng, Dong-mei Wu, Yuan-Lin Zheng, Xiao-hui Wang, Jie Ruan, Xiao Sun, Qun Shan, Zi-feng Zhang. Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. Neurobiology of Learning and Memory, 2011, 96: 156-165 (2011 IF=3.419)

8. Jun Lu, Dong-mei Wu, Zi-hui Zheng, Yuan-lin Zheng, Bin Hu, Zi-feng Zhang. Troxerutin protects against high cholesterol-induced cognitive deficits in mice.Brain,2011, 134: 783–797 (2011 IF=9.457)

9. Jun Lu, Dong-mei Wu, Yuan-lin Zheng, Bin Hu, Zi-feng Zhang, Qun Shan, Zi-hui Zheng, Chan-min Liu, Yong-jian Wang. Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity. Journal of Pathology, 2010, 222: 199-212. (2010 IF=7.274)

10. Jun Lu, Dong-mei Wu, Yuan-lin Zheng, Bin Hu, Zi-feng Zhang, Qin Ye, Chan-min Liu, Qun Shan, and Yong-jian Wang. Ursolic Acid Attenuates D-Galactose-Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF-κB Pathway Activation. Cerebral Cortex, 2010, 20: 2540-2548. (2010 IF=6.844)

11. Jun Lu, Dong-mei Wu, Bin Hu, Yuan-lin Zheng, Zi-feng Zhang, Yong-jian Wang. NGF-dependent activation of TrkA pathway, a mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice. Brain Pathology, 2010, 20: 952-965. (2010 IF=4.741)

12. Yong-jian Wang, Yuan-lin Zheng, Jun Lu, Guo-qing Chen, Xiao-hui Wang, Jie Feng, Jie Ruan, Xiao Sun, Chun-xiang Li, Qiu-ju Sun. Purple sweet potato color suppresses lipopolysaccharide-induced acute inflammatory response in mouse brain. Neurochemistry International, 2010, 56: 424-430. (2010 IF=3.601)

13. Jun Lu, Dong-mei Wu, Yuan-lin Zheng, Bin Hu, Zi-feng Zhang. Purple Sweet Potato Color Alleviates D-galactose-induced Brain Aging in Old Mice by Promoting Survival of Neurons via PI3K Pathway and Inhibiting Cytochrome C-mediated Apoptosis. Brain Pathology, 2010, 20: 598-612. (2010 IF=4.741)

14. Jun Lu, Dong-mei Wu, Bin Hu, Wei Cheng, Yuan-lin Zheng, Zi-feng Zhang, Qin Ye, Shao-hua Fan, Qun Shan, Yong-jian Wang. Chronic administration of troxerutin protects mouse brain against d-galactose-induced impairment of cholinergic system. Neurobiology of Learning and Memory, 2010, 93: 157-164. (2010 IF=3.701)

15. Jun Lu, Yuan-lin Zheng, Dong-mei Wu, Dong-xu Sun, Qun Shan, Shao-hua Fan. Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway. Brain, Behavior, and Immunity, 2009, 23: 193-203. (2009 IF=5.061)

16. Dong-mei Wu, Jun Lu, Yuan-lin Zheng, Zhong Zhou, Qun Shan, Dai-fu Ma. Purple sweet potato color repairs D-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins. Neurobiology of Learning and Memory, 2008, 90: 19-27. (2008 IF=3.757)

17. Jun Lu, Yuan-Lin Zheng, Dong-Mei Wu, Lan Luo, Dong-Xu Sun Qun Shan.Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Biochemical Pharmacology, 2007, 74:1078-1090. (2007 IF=4.006)

18. Jun Lu, Yuan-lin Zheng, Dong-mei Wu, Dong-xu Sun, Qun Shan, Shao-hua Fan. Trace amounts of copper induce neurotoxicity in the cholesterol-fed mice through apoptosis.FEBS Letters, 2006, 580: 6730-6740. (2006 IF=3.372)


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